Jules follows Milton (Kingsley) who lives a quiet life of routine in a small western Pennsylvania town, but finds his day upended when a UFO and its extra-terrestrial passenger crash land in his backyard. Before long, Milton develops a close relationship with the extra-terrestrial he calls “Jules.” Things become complicated when two neighbors (Harris and Curtin) discover Jules and the government quickly closes in. What follows is a funny, wildly inventive ride as the three neighbors find meaning and connection later in life – thanks to this unlikely stranger.