Rose Lorkowski (Adams), a former high school cheerleader and now a thirty-something maid, is trying to create a better life for herself and her eccentric eight-year-old son Oscar (Spevack). Her burn-out younger sister Norah (Blunt) still lives at home with their father Joe (Arkin), who’s on the latest of a life-long string of get-rich-quick schemes. When Rose learns of the big money to be made in the crime scene cleaning and bio-hazard removal business, she and Norah partner up to create their own company, Sunshine Cleaning. The venture proves useful in helping the girls clean up their own lives as well as what’s left of the lives of others.